Pentobarbital will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 me... https://bookmarkbooth.com/story20321616/considerazioni-da-sapere-su-pentobarbital-euthanasia-for-dogs