The degradation approach alone does not cause ache because articular cartilage lacks innervation. However, ache occurs as a result of articular cartilage thinning, stimulating ache fibers in close by regions. The joint's problems response is synovial fluid output, resulting in swelling and inflammation that stretches the remarkably innervated articular capsule https://www.amazon.com/dp/B082XJ4R2F